Composition w/v
Moxifloxacin Hydrochloride
Equivalent to Moxifloxacin
Sterile Aqueous Base
Dosage form Ophthalmic Solution (Eye Drops)
Category:
Antibiotic
0.5%
q.s.
Description:
Moxifloxacin is an 8-methoxy fluoroquinolone with a diazabicyclononyl ring at the C7 position. The antibacterial action of moxifloxacin results from inhibition of the topoisomerase II (DNA gyrase) and topoisomerase IV. DNA gyrase is an essential enzyme that is involved in the replication, transcription and repair of bacterial DNA. Topoisomerase IV is an enzyme known to play a key role in the partitioning of the chromosomal DNA during bacterial cell division.
Indications:
Moxifloxacin ophthalmic solution is indicated for the treatment of bacterial conjunctivitis.
Contraindications:
Moxifloxacin ophthalmic solution is contraindicated in patients with a history of hypersensitivity to moxifloxacin, to other quinolones, or to any of the components in this medication.
Warning & Precautions:
As with other anti-infectives, prolonged use may result in overgrowth of non-susceptible organisms, including fungi. If superinfection occurs, discontinue use and institute alternative therapy. Whenever clinical judgment dictates, the patient should be examined with the aid of magnification, such as slit-lamp biomicroscopy, and, where appropriate, fluorescein staining. Patients should be advised not to wear contact lenses if they have signs and symptoms of bacterial conjunctivitis.
Lactation:
Moxifloxacin has not been measured in human milk, although it can be presumed to be excreted in human milk. Caution should be exercised when moxifloxacin solution is administered to a lactating female.
Adverse Effects:
The most frequently reported ocular undesirable effects were conjunctivitis, decreased visual acuity, dry eye, keratitis, ocular discomfort, ocular hyperemia, ocular pain, ocular pruritus, sub-conjunctival hemorrhage, and tearing. These events occurred in approximately 1-6% of patients.
Adverse Effects:
Headaches have been reported at an incidence of 7%. The following undesirable effects have been reported in less than 5% of patients: asthenia, blurred vision, burning or stinging, cold syndrome, dry eye, foreign body sensation, hyperemia, hypersensitivity, keratitis, lid edema, nausea, pharyngitis, pruritus, rhinitis, sinusitis, and taste perversion. Some of these events were similar to the underlying disease being studied.
Storage:
Store in a cool dry place. Protect from light.
Presentation
Rvdrops Eye Drops is available in sterile plastic bottle of 5 ml.
Description:
Broad Spectrum antibiotic with good activity against S. aureus, Streptococcus species and Gram-negative pathogens.
Reduces the frequency of conjunctival bacterial growth.
Effective preperative regimen for eyes undergoing anterior segment surgery
Show efficacy of 94% & exhibits lowest MIC than levofloxacin in bacterial conjunctivities
Demonstrates greater ocular tolerability as compared to moxifloxacin
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